Aging and Hyaluronic Acid

Aging determines a decrease of HA, reduction of fibroblasts activity, down regulation of CD44 and RHAMM receptors as well as all gene-transcriptors for HA, increase of Hyaluronidase

Sunekos Performa is the new innovation in aesthetic medicine from Sunekos Laboratories.

It is composed of low molecular weight hyaluronic acid and the patented cluster of Amino Acids, the HY6AA formula, in a new ratio “AA vs HA” allowing a significant reduction of the hyaluronidase action:

A study on Sunekos Performa demonstrated that the presence of its specific combination of AAs (HY6AA formula), that through a physical action decreases the degradation of HA, by reducing the Hyaluronidase mediated process.

Therefore, the study suggests that Sunekos Performa, thanks to this new balancing of AA vs HA, will persist longer and it will be more effective as the HA can stimulate the receptors for longer time.

This action has been confirmed by:

  1. contrasting the hydrophilic properties of HA employing the 6AA hydrophobic amino acids formula; [1]
  2. contrasting the overall negative electrical charge of HA using a strong positively charged amino acid as Lysine [1]
increase and prolong hyaluronic acid

Sunekos Performa rebuilds the Extra Cellular Matrix in a more effective and complete way, by stimulating:

  • Elastin (Eln) [7]
  • Collagen, including all main types of reticular collagen fibres of the dermis and Type IV and Type VII (anchoring types, plaques and fibres) [5] [7]
  • Fibronectin (Fbn1) [7]

ECM model

  • Collagen Type IV Anchors Plaque
  • Collagen Type VII Anchors Fibrils
  • Fibronectin plays a major role in cell adhesion, and in anchoring reticular collagen fibres and cells.
  • Collagen Type IV Anchors Plaque
  • Collagen Type VII Anchors Fibrils
  • Fibronectin plays a major role in cell adhesion, and in anchoring reticular collagen fibres and cells.

Indication: wrinkles and skin laxity

Full Face

Periocular Area

Neck

Décolleté

Hands

“Sunekos Performa can also be used to treat periocular area, neck, décolleté and hands upon specific training with qualified personnel”

Full Face Protocol

3 Sessions Protocol. The first injection of Sunekos Performa has to be done together with Sunekos 1200

Sunekos Performa Protocol

Face Injection Technique

Logo Sunekos 1200
Needle
  • Needle 27-30G and 13mm
  • 1ml syringe (recommended)
  • Medium/deep DERMIS
  • Only 1st session before injecting Sunekos Performa
Cannula and needle
  • Cannula 25-27-30G and 40mm
  • Needle 27-30G and 13 mm
  • Medium/deep DERMIS
  • Only 1st session before injecting Sunekos Performa

NOTE: this only a guide and it is not meant to be a substitution for in person training.
Before using any Sunekos product plese ENSURE that you have received full training from a qualified instructor.

Face Injection Technique

Logo Sunekos Performa
Mid + Lower Third
  • Needle 30-32G and 4-13mm
  • 1ml syringe (recommended)
  • Medium/deep DERMIS
  • Perpendicular to the Folding Lines
  • 1 session every 2 weeks for 3 times (a 4th is optional depending on the patient)
Full Face
  • Needle 27-30G and 13mm
  • 1ml syringe (recommended)
  • Medium/deep DERMIS
  • Only 1st session before injecting Sunekos Performa

NOTE: this only a guide and it is not meant to be a substitution for in person training.
Before using any Sunekos product plese ENSURE that you have received full training from a qualified instructor.

Studies

A study on Sunekos Performa demonstrated that the presence of its specific combination of AAs (HY6AA formula), with their ancillary action, decreases the degradation of HA by reducing the Hyaluronidase process, by reducing the Hyaluronidase process [1].

Therefore, the study suggests that Sunekos Performa, thanks to the new ratio “AA versus HA”, will persist longer and it will be more effective as the HA can stimulate the receptors over an extended period.

BEFORE AND AFTER

Courtesy by Elena Fasola

Courtesy by Elena Fasola

Courtesy by Mark Holmes

Courtesy by Elena Fasola

References

  1. Measurement of hyaluronidase activity on hyaluronic acid in presence or absence of a specific amino acid formula – Laura Tedesco and Enzo Nisoli [under publication]
  2. The role of hydrophobic modification on hyaluronic acid dynamics and self-assembly. Carbohydr Polym – Payne WM , Svechkarev D , Kyrychenko A , Mohs AM . 2018 Feb 15;182:132-141. doi: 10.1016/j.carbpol.2017.10.054
  3. Modified hyaluronic acid based materials for biomedical applications – Tiwari S , Bahadur P.. Int J Biol Macromol. 2019 Jan;121:556-571. doi: 10.1016/j.ijbiomac.2018.10.049.
  4. Sealing hyaluronic acid microgels with oppositely-charged polypeptides: A simple strategy for packaging hydrophilic drugs with on-demand release. – Labie H , Perro A , Lapeyre V , Goudeau B , Catargi B , Auzély R , Ravaine V. J Colloid Interface Sci. 2019 Feb 1;535:16-27. doi: 10.1016/j.jcis.2018.09.048
  5. Amino acid and hyaluronic acid mixtures differentially regulate extra cellular matrix genes in cultured human fibroblasts – B De Servi A Orlandini E Caviola – M Meloni Biol Regul Homeost Agents. May-Jun 2018;32(3):517-527. PMID: 29921376)
  6. Kutera – Fasola
  7. 6 AA fibronectin studio

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