Aging determines a decrease of HA, reduction of fibroblasts activity, down regulation of CD44 and RHAMM receptors as well as all gene-transcriptors for HA, increase of Hyaluronidase
Aging and Hyaluronic Acid
Sunekos Performa is the new innovation in aesthetic medicine from Sunekos Laboratories.
It is composed of low molecular weight hyaluronic acid and the patented cluster of Amino Acids, the HY6AA formula, in a new ratio “AA vs HA” allowing a significant reduction of the hyaluronidase action[1;2;3;4].
A study on Sunekos Performa demonstrated that the presence of its specific combination of AAs (HY6AA formula), that through a physical action decreases the degradation of HA, by reducing the Hyaluronidase mediated process.
Therefore, the study suggests that Sunekos Performa, thanks to this new balancing of AA vs HA, will persist longer and it will be more effective as the HA action can promote a longer duration[1].
Sunekos Performa helps to rebuild the Extra Cellular Matrix in a more effective and complete way, by promoting the production of:
ECM model
Indication: wrinkles and skin laxity
Full Face
Periocular Area
Neck
Décolleté
Hands
“Sunekos Performa can also be used to treat periocular area, neck, décolleté and hands upon specific training with qualified personnel”
Studies
A study on Sunekos Performa demonstrated that the presence of its specific combination of AAs (HY6AA formula), with their ancillary action, decreases the degradation of HA by reducing the Hyaluronidase process, by reducing the Hyaluronidase process [1].
Therefore, the study suggests that Sunekos Performa, thanks to the new ratio “AA versus HA”, will persist longer and it will be more effective as the HA can stimulate the receptors over an extended period.
BEFORE AND AFTER
Courtesy by Elena Fasola
Courtesy by Elena Fasola
Courtesy by Mark Holmes
Courtesy by Elena Fasola
References
- Measurement of hyaluronidase activity on hyaluronic acid in presence or absence of a specific amino acid formula – Laura Tedesco and Enzo Nisoli [under publication]
- The role of hydrophobic modification on hyaluronic acid dynamics and self-assembly. Carbohydr Polym – Payne WM , Svechkarev D , Kyrychenko A , Mohs AM . 2018 Feb 15;182:132-141. doi: 10.1016/j.carbpol.2017.10.054
- Modified hyaluronic acid based materials for biomedical applications – Tiwari S , Bahadur P.. Int J Biol Macromol. 2019 Jan;121:556-571. doi: 10.1016/j.ijbiomac.2018.10.049.
- Sealing hyaluronic acid microgels with oppositely-charged polypeptides: A simple strategy for packaging hydrophilic drugs with on-demand release. – Labie H , Perro A , Lapeyre V , Goudeau B , Catargi B , Auzély R , Ravaine V. J Colloid Interface Sci. 2019 Feb 1;535:16-27. doi: 10.1016/j.jcis.2018.09.048
- Amino acid and hyaluronic acid mixtures differentially regulate extra cellular matrix genes in cultured human fibroblasts – B De Servi A Orlandini E Caviola M Meloni – Biol Regul Homeost Agents. May-Jun 2018;32(3):517-527. PMID: 29921376)
- Pilot study evaluating the therapeutic effects of a new pre-mixed injectable product of low molecular weight (LMW) hyaluronic acid added to six amino acids (HY6AA +Formula) in facial skin aging. – Fasola E, Kutera E. J Dermat Cosmetol.
2022;6(3):74-77 - A designer mixture of six amino acids promotes the extracellular matrix gene expression in cultured human fibroblasts. – Tedesco L., Rossi F. Ruocco C., Ragni M., Carruba M.O., Valerio A., Nisoli E. Bioscience, Biotechnology and Biochemistry,
2022, Vol. 86, No. 9, 1255-1261